Effects of the administration of aqueous extract of de Sedum dendroideum on the histopathology of erosive induced gastritis by means of indomethacin in rats
AUTOR(ES)
Baracho, Nilo Cesar do Vale, Ribeiro, Rafaela Vazi, Pereira, Renato Maduro, Irulegui, Roseane de Souza Candido
FONTE
Acta Cir. Bras.
DATA DE PUBLICAÇÃO
2014-01
RESUMO
PURPOSE: To evaluate the effects of acute administration of Sedum dendroideum on the gastric histopathology of rats after the administration of indomethacin. METHODS: Twenty four Wistar rats were randomized into three groups, submitted to feeding privation for 24 hours prior to the oral administration of 50 mg/Kg of indomethacin and during the experimental period of six hours. The control group (C) was giving distilled water, the extract group (E) was treated with the extract of Sedum dendroideum and the group Omeoprazole (O) received 20 mg/Kg of omeoprazole. All the treatments were carried out thirty minutes prior to the administration of indomethacin. After six hour, the stomach of the animals was extirpated for histopathological analysis, which took into account the presence of erosive gastritis, hyperemia and sub mucosa edema. RESULTS: In group C, eight out of eight animals presented that type of lesion, in group E, this number was the same and in group O, three out of the eight rats presented erosive gastritis. CONCLUSION:
Documentos Relacionados
- Cardiovascular effects induced by the aqueous fraction of the ethanol extract of the stem of Solanum stipulaceum in rats
- Hypoglycemic effect of okra aqueous extract on streptozotocin-induced diabetic rats
- Nephroprotective and anti-inflammatory effects of aqueous extract of Melissa officinalis L. on acetaminophen-induced and pleurisy-induced lesions in rats
- Gastroprotective and antioxidant effects of Eremurus spectabilis Bieb. methanol extract and its isolated component isoorientin on indomethacin induced gastric ulcers in rats
- The effects of aqueous extract of babassu (Orbignya phalerata) on the pleura and lung parenchyma in rats