Effects of sublethal concentrations of antimicrobial agents on the hemagglutination, adhesion, and ultrastructure of pyelonephritogenic Escherichia coli strains.
AUTOR(ES)
Väisänen, V
RESUMO
The effects of trimethoprim, sulfadiazine, sulfamethoxazole, and sulfathiazole on the hemagglutination and adhesion by three Escherichia coli strains were studied. The strains were isolated from the urine of patients with acute pyelonephritis and carried P antigen-recognizing fimbriae (P fimbriae). At antimicrobial concentrations of 12.5 to 50% of the minimal inhibitory concentration, the ability of the bacteria to agglutinate human erythrocytes and to adhere to human buccal cells was markedly reduced. This reduction corresponded to a decrease in the number of P fimbriae per cell, suggesting that the antimicrobial agents decreased adhesion and hemagglutination by interfering with the formation of fimbriae. No major changes were observed in the outer membrane protein pattern of trimethoprim-treated cells, whereas freeze-fracture electron micrographs showed deorganization of both the cytoplasmic and outer membranes in bacteria opposed to sublethal concentrations of trimethoprim.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=183684Documentos Relacionados
- Adhesion, hemagglutination, and virulence of Escherichia coli causing urinary tract infections.
- Hemagglutination, autoagglutination and pathogenicity of Moraxella bovis strains.
- Adhesion, biofilm and genotypic characteristics of antimicrobial resistant Escherichia coli isolates
- Pilus Production, Hemagglutination, and Adhesion by Porcine Strains of Enterotoxigenic Escherichia coli Lacking K88, K99, and 987P Antigens
- Effect of subinhibitory concentrations of mecillinam on the serum susceptibility of Escherichia coli strains.