Effects of pH on the Activity of Ketoconazole Against Candida albicans

AUTOR(ES)
RESUMO

The activity of ketoconazole against Candida albicans in Sabouraud glucose medium was markedly influenced by pH. Minimum inhibitory concentrations of this imidazole against both a standard strain and clinical isolates ranged from 40 μg/ml at pH 3 to 0.02 μg/ml at pH 7, a greater than 1,000-fold difference.

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