Effects of N-Hydroxyurethan on Viability and Metabolism of Escherichia coli
AUTOR(ES)
Mullinix, Kathleen P.
RESUMO
Exposure of growing cells to low levels of N-hydroxyurethan (approximately 0.05 m) resulted in loss of colony-forming ability. This was accompanied by degradation of cellular deoxyribonucleic acid. When the concentration of N-hydroxyurethan was increased to 0.2 m, bacteriostasis was the primary manifestation. The lethal action of the drug was prevented by contreatment with chloramphenicol or azauracil or by uracil-deprivation of a bacterial strain requiring this pyrimidine for growth.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=248421Documentos Relacionados
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