Effects of gallic acid and physical exercise on passive avoidance memory in male rat
AUTOR(ES)
Salehi, Azadeh
FONTE
Braz. J. Pharm. Sci.
DATA DE PUBLICAÇÃO
24/10/2019
RESUMO
Learning and memory play main roles in daily life of human, and memory represents the basis of all trainings and learning. The aim of the current study is to investigate the effects of gallic acid and physical exercise on the levels of passive avoidance memory in rat. In this experimental study, 46 rats weighing 200-300 g were randomLy divided to six groups of eight each: including control group, groups treated with 10 and 20 mg/kg gallic acid, group undergoing physical exercise alone, and groups both undergoing physical exercise and treated with 10 and 20 mg/kg gallic acid. The interventions continued for 10 days. After the intervention, passive avoidance memory was measured by shuttle box, blood samples were taken, and serum and brain antioxidant capacity and malondialdehyde (MDA) levels were measured. Secondary latency in shuttle box significantly increased in groups undergoing treadmill exercise and undergoing treadmill exercise + treating 10 and 20 mg/kg gallic acid. In groups treated with 10 and 20 mg/kg gallic acid alone, secondary latency increased significantly. Results confirmed the effects of gallic acid and physical exercise, either alone or combined, in improving memory.
Documentos Relacionados
- Effects of acute and chronic physical exercise and stress on different types of memory in rats
- Effects of carvacrol and physical exercise on motor and memory impairments associated with Parkinson’s disease
- Cholinergic ventral forebrain grafts into the neocortex improve passive avoidance memory in a rat model of Alzheimer disease.
- Acute physical and psychological stress effects on visceral hypersensitivity in male rat: role of central nucleus of the amygdala
- Effects of physical exercise on butyrylcholinesterase in obese adolescents