Effects of extracts of Trypanosoma cruzi on immune responses: induction of a nonspecific suppressor factor.
AUTOR(ES)
Tarleton, R L
RESUMO
Extracts of epimastigotes of Trypanosoma cruzi were examined for the ability to augment or suppress in vivo and in vitro responses of mouse spleen cells. When administered to mice 4 days before immunization with sheep erythrocytes, the 12,000 X g pellet and the 104,000 X g pellet and supernatant fractions of extracts of T. cruzi had no effect on the subsequent plaque-forming cell responses. Testing of the two 104,000 X g fraction in vitro resulted in a slight dose-dependent modification of anti-sheep erythrocyte responses. Also, these two fractions had a moderate dose-dependent blastogenic effect on normal spleen cells. Most significantly, the 104,000 X g supernatant fraction elicited the production of a suppressor factor when incubated with spleen cells from infected mice. This suppressor factor was also apparent when spleen cells from infected mice were incubated with intact epimastigotes or trypomastigotes. Production of the suppressor factor was insensitive to indomethacin and, therefore, presumably was not a prostaglandin.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=264597Documentos Relacionados
- Gastric invasion by Trypanosoma cruzi and induction of protective mucosal immune responses.
- Molecular cloning and characterization of a cDNA encoding monoclonal nonspecific suppressor factor.
- The effects of nitric oxide on the immune system during Trypanosoma cruzi infection
- Evasion of immune responses by Trypanosoma cruzi, the etiological agent of Chagas disease
- 15d-PGJ2 modulates acute immune responses to Trypanosoma cruzi infection