Effects of estrogen replacement therapy in hemodinamic and neural responses to acute aerobic exercise in post-menopausal women / Efeitos isolados e associados da terapia de reposição oral estrogênica e do exercício físico aeróbico nas respostas hemodinâmicas e neurais em mulheres no período pós-menopausa

AUTOR(ES)

Bruna Oneda

DATA DE PUBLICAÇÃO

2010

RESUMO

The post-menopause is marked by physiological hemodynamic and metabolic changes. The estrogen replacement therapy is a way to reduce the consequences of hormone deficiency and physical exercise contributes significantly to the reduction of cardiovascular risk. The aim of this study was to evaluate in post-menopausal women the isolated and associated effects of oral estrogen therapy (TRH) and physical training (TF) in the neural and hemodynamic responses during baseline and "handgrip" exercises. Forty-five women (51 ± 3 years), hysterectomized, with or without ovaries, healthy, participated of an initial session and then they were divided into 4 groups SEDPLA (n = 11), SED-TRH (n = 14), TF-PLA (n = 12) and TF-TRH (n = 8). The TRH groups received estradiol valerate 1 mg / day; PLA placebo; TF, performed aerobic exercise on a cycle ergometer for 50 minutes, 3 times a week and SED remained sedentary. All subjects participated in a second experimental session after 6 months of follow-up. In the experimental sessions peripheral sympathetic nerve activity (ANSP - microneurography), blood pressure, heart rate (FC - oscillometry - Dixtal lower limb), forearm blood flow (FSA - plethysmography) were evaluated at the baseline period and during static and dynamic "handgrip" exercises at 30% of the maximum force. ANOVA was used for the statistica analysis. The TF alone decreased ANSP from 40 ± 7 to 34 ± 4 bursts/min, P = 0.01 and increased FSA 1.92 ± 0.96 to 2.65 ± 1.34 ml (min.100ml), P = 0.03 at the baseline. The association of TRH and TF reduced HR at the baseline from 65 ± 8 to 62 ± 7 bpm (P=0.01) and during exercise with static and dynamic "handgrip". HRT alone or associated with TF decreased the HR responses during static and dynamic "handgrip exercises. In conclusion, the interventions alone or in an associated way promote neural and hemodynamic changes that may contribute to cardiovascular risk reduction in healthy postmenopausal women.

ASSUNTO(S)

exercício terapia de reposição de estrogênios hormone replacement therapy sistema nervoso simpático estrogen replacement therapy postmenopause terapia de reposição hormonal exercise pós-menopausa sympathetic nerve system

Documentos Relacionados

• Efeitos da terapia de reposição estrogênica nas respostas hemodinâmicas e neurais ao exercício físico agudo em mulheres no período pós-menopausa
• Terapia estrogênica para osteoporose na pós-menopausa
• Exercício aeróbico no controle da hipertensão arterial na pós-menopausa
• Effects of oral estrogen therapy and aerobic training on insulin sensitivity and hemodynamic and autonomic responses to acute hiperinsulinemia in postmenopausal women
• Exercício físico e fatores de risco cardiovasculares em mulheres obesas na pós-menopausa