Effects of diet and exercise training on neurovascular control during mental stress in obese women

AUTOR(ES)

Tonacio, A.C., Trombetta, I.C., Rondon, M.U.P.B., Batalha, L.T., Kuniyoshi, F.H.S., Laterza, M.C., Suzuki, P.H., Gowdak, M.M.G., Barretto, A.C.P., Halpern, A., Villares, S.M.F., Negrão, C.E.

FONTE

Brazilian Journal of Medical and Biological Research

DATA DE PUBLICAÇÃO

2006-01

RESUMO

Since neurovascular control is altered in obese subjects, we hypothesized that weight loss by diet (D) or diet plus exercise training (D + ET) would improve neurovascular control during mental stress in obese women. In a study with a dietary reduction of 600 kcal/day with or without exercise training for 4 months, 53 obese women were subdivided in D (N = 22, 33 ± 1 years, BMI 34 ± 1 kg/m²), D + ET (N = 22, 33 ± 1 years, BMI 33 ± 1 kg/m²), and nonadherent (NA, N = 9, 35 ± 2 years, BMI 33 ± 1 kg/m²) groups. Muscle sympathetic nerve activity (MSNA) was measured by microneurography and forearm blood flow by venous occlusion plethysmography. Mental stress was elicited by a 3-min Stroop color word test. Weight loss was similar between D and D + ET groups (87 ± 2 vs 79 ± 2 and 85 ± 2 vs 76 ± 2 kg, respectively, P < 0.05) with a significant reduction in MSNA during mental stress (58 ± 2 vs 50 ± 2, P = 0.0001, and 59 ± 3 vs 50 ± 2 bursts/100 beats, P = 0.0001, respectively), although the magnitude of the response was unchanged. Forearm vascular conductance during mental stress was significantly increased only in D + ET (2.74 ± 0.22 vs 3.52 ± 0.19 units, P = 0.02). Weight loss reduces MSNA during mental stress in obese women. The increase in forearm vascular conductance after weight loss provides convincing evidence for D + ET interventions as a nonpharmacologic therapy of human obesity.

Documentos Relacionados

• EFFECTS OF AEROBIC EXERCISE TRAINING ON OXIDATIVE STRESS IN THE SKELETAL MUSCLES OF OBESE RATS
• Effects of exercise training and diet on lipid kinetics during free fatty acid-induced insulin resistance in older obese humans with impaired glucose tolerance
• Interaction of training and diet on metabolism and endurance during exercise in man.
• Effects of exercise and low-fat diet on adipose tissue inflammation and metabolic complications in obese mice
• Effects of exercise training on neurovascular control in heart failure patients treated with Carvedilol