Effects of Copaiba oil in the healing process of urinary bladder in rats
AUTOR(ES)
Feitosa Junior, Denilson José Silva, Carvalho, Luan Teles Ferreira de, Rocha, Ingrid Rodrigues de Oliveira, Brito, Camila Noura de, Moreira, Rodrigo Alencar, Barros, Charles Alberto Villacorta de
FONTE
Int. braz j urol.
DATA DE PUBLICAÇÃO
2018-04
RESUMO
ABSTRACT Introduction The appropriate closure of the urinary bladder is important to many urologic procedures to avoid the formation of fistulas and strictures by excessive fibrosis. This paper presents the alterations in the bladder healing process of rats after the topical use of Copaiba oil (Copaifera reticulata). Material and Methods Ten male Wistar rats were used and randomly divided into two groups: Control group (CG): injected 1ml/kg of saline solution on the suture line; and Copaiba group (CpG): 0.63ml/kg of copaiba oil applied to the suture line. Euthanasia was performed on the seventh day after surgery. The criteria observed were adherences formation, histopathological modifications and stereology for collagen. Results Both groups showed adhesions to the bladder, with no statistically significant difference (p=0.1481). The microscopic evaluation revealed a trend to more severe acute inflammation process on the CpG, but there was statistical difference only in the giant cells reaction (p=0.0472) and vascular proliferation (p=0.0472). The stereology showed no difference. Conclusion The copaiba oil modified the healing process, improving the quantity of giant cells and vascular proliferation, but not interfered in the collagen physiology.
Documentos Relacionados
- Effects of the topical administration of copaiba oil ointment (Copaifera langsdorffii) in skin flaps viability of rats
- Attenuation of copaiba oil in hepatic damage in rats
- Effects of aroeira (Schinus terebinthifoliu Raddi) oil on cutaneous wound healing in rats
- Effects of the application of the amniotic membrane in the healing process of skin wounds in rats
- Copaiba oil effect on induced fecal peritonitis in rats