Effects of Chloramphenicol on the Circadian Rhythm of Neurospora crassa1
AUTOR(ES)
Frelinger, John G.
RESUMO
Chloramphenicol, an inhibitor of mitochondrial protein synthesis, shortened the period length of the circadian rhythm in the Timex strain of Neurospora crassa by 2 hours. Both the l(+) threo and d(−) threo optical isomers had the same effect on the period of the rhythm, whereas only the d(−) threo isomer significantly inhibited mitochondrial protein synthesis. Tetracycline, another inhibitor of mitochondrial protein synthesis, did not change the period of the circadian rhythm. The effect of chloramphenicol on the circadian rhythm is, therefore, presumably not directly related to inhibition of mitochondrial protein synthesis, suggesting that chloramphenicol has other effects.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=543288Documentos Relacionados
- Circadian Nature of a Rhythm Expressed by an Invertaseless Strain of Neurospora crassa1
- A Failure to Detect an Influence of Magnetic Fields on the Growth Rate and Circadian Rhythm of Neurospora crassa1
- Temperature Compensation of Circadian Period Length in Clock Mutants of Neurospora crassa1
- Assay and Characteristics of Circadian Rhythmicity in Liquid Cultures of Neurospora crassa1
- Spatial Distribution of Circadian Clock Phase in Aging Cultures of Neurospora crassa1