Effect of the leucine overload in rat soleus muscle during gradual distraction osteogenesis. / Efeito da sobrecarga de leucina no músculo sóleo de ratos durante a distração gradual osteogênica.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2007

RESUMO

The goal of the present study was to investigate the effect of leucine overload in the rat soleus muscle before and along DGO (Gradual Distraction Osteogenesis). Twenty five male Wistar rats were divided into 5 groups: control, sham-lengthening, leucine, DGO and DGO+leucine. The DGO was 2mm/day and the leucine overload (114mM) was administrated orally. Subsequently analyzed: histological cross-section, sarcomere serial number and cross-sectional area of the types fibers and connective tissue. The histological data showed that the DGO promoted intense injury and increase of connective tissue, which can be minimized by leucine. The sarcomere serial number increased by ~26% and leucine overload increased this gain to 33%. The fibers types showed a decrease of the cross-section area of the all type fibers with the DGO and increase of the type I fibers area with leucine overload. We conclude that leucine overload is a potential therapeutical device in DGO, seeking improvement of skeletal muscle longitudinal growth.

ASSUNTO(S)

muscle injury trofismo muscular dano muscular sarcomerogenesis gradual distraction osteogenesis músculo esquelético skeletal muscle muscle trophism sarcomerogênese distração gradual osteogênica leucine leucina

ACESSO AO ARTIGO

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