Effect of Terminal Aneuploidy on Epidermal Cell Viability in DROSOPHILA MELANOGASTER

AUTOR(ES)

Ripoll, Pedro

RESUMO

In Drosophila melanogaster, individuals heterozygous for translocations between chromosomes Y and 3 can generate, by means of mitotic recombination, somatic cells bearing duplications and deletions. Using translocations with different breakpoints, I have studied the behavior of clones of cells with increasing degrees of aneuploidy in the abdominal cuticle. Both hyper- and hypoploid cells can survive being duplicated or deficient even for large chromosome 3 fragments. While hyperploidy does not severely affect cell viability, the recovery of hypoploid clones decreases linearly as a function of the size of the deleted fragment. In this report, the quantitative and qualitative aspects of this effect are discussed.

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