Effect of spectinomycin on T. pallidum in incubating experimental syphilis.
AUTOR(ES)
Petzoldt, D
RESUMO
Animal experiments were performed to determine if a single-dose treatment for acute gonorrhoea with 2 g. spectinomycin could cure a simultaneously acquired syphilis at a very early stage of incubation. 300 treponemes (Nichols stain T. pallidum) were inoculated intratesticularly and 3 days later spectinomycin was administered in a dose which produced spectinomycin serum levels similar to those in patients who had received a single oral dose of 2 g. This dosage of spectinomycin did not prevent the development of syphilitic orchitis or reactivity to the FTA-ABS test, but it prolonged the subclinical incubation period.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1045166Documentos Relacionados
- Effect of ofloxacin on Treponema pallidum in incubating experimental syphilis.
- Single-dose treatment of gonorrhoea with penicillin or thiamphenicol and its effect on T. pallidum in experimental syphilis.
- Persistence of T. pallidum and its significance in penicillin-treated seropositive late syphilis.
- Treponema pallidum-immobilizing antibodies in guinea pig experimental syphilis.
- Effects of cefetamet (Ro 15-8074) on Treponema pallidum and experimental syphilis.
