Effect of repeated restraint stress on memory in different tasks

AUTOR(ES)

Gamaro, Giovana Duzzo

DATA DE PUBLICAÇÃO

2010

RESUMO

The present study investigated the effect of repeated stress applied to female rats on memory evaluated by three behavioral tasks: two-way shuttle avoidance, inhibitory avoidance and habituation to an open field. Repeated stress had different effects on rat behavior when different tasks were considered. In the two-way active avoidance test the stressed animals presented memory of the task, but their memory scores were impaired when compared to all other groups. In the habituation to the open field, only the control group showed a significant difference in the number of rearings between training and testing sessions, which is interpreted as an adequate memory of the task. In the handled and chronically stressed animals, on the other hand, no memory was observed, suggesting that even a very mild repeated stress would be enough to alter habituation to this task. The performance in the inhibitory avoidance task presented no significant differences between groups. The findings suggest that repeated restraint stress might induce cognitive impairments that are dependent on the task and on stress intensity.

ASSUNTO(S)

chronic stress bioquímica memory inhibitory avoidance two-way active avoidance open field

Documentos Relacionados

• Effect of acute and repeated restraint stress on glucose oxidation to CO2 in hippocampal and cerebral cortex slices
• Effect of acute and repeated restraint stress on glucose oxidation to CO2 in hippocampal and cerebral cortex slices
• Interaction between repeated restraint stress and concomitant midazolam administration on sweet food ingestion in rats
• Interaction between repeated restraint stress and concomitant midazolam administration on sweet food ingestion in rats
• Plasma native and peptidase-derivable Met-enkephalin responses to restraint stress in rats. Adaptation to repeated restraint.