Effect of prostaglandin E1 on certain renal actions of parathyroid hormone
AUTOR(ES)
Beck, Nama P.
RESUMO
Parathyroid hormone increased basal adenyl cyclase activity and that increase was inhibited by prostaglandin E1 (PGE1). Tissue cyclic 3′,5′-adenosine monophosphate (cyclic AMP) concentrations were increased by parathyroid hormone and that increase was likewise inhibited by PGE1. Both parathyroid hormone and dibutyryl cyclic AMP increased 32P incorporation into renal cortical phospholipids. PGE1 diminished the effect of parathyroid hormone but not dibutyryl cyclic AMP to influence that parameter. PGE1 likewise modulated the effect of parathyroid hormone but not dibutyryl cyclic AMP to decrease fractional phosphate reabsorption by the renal tubule. It is suggested that PGE1 inhibits the effect of parathyroid hormone by decreasing its effect on adenyl cyclase. Such interaction may be important in modulating the intracellular action of parathyroid hormone on kidney cortex.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=292402Documentos Relacionados
- Direct Inhibitory Effect of Hypercalcemia on Renal Actions of Parathyroid Hormone
- Mechanism of Effect of Prostaglandin E1 on Renal Water Excretion
- Effects of Ca++ and Prostaglandin E1 on Vasopressin Activation of Renal Adenyl Cyclase
- A micropuncture study of the effect of parathyroid hormone on renal bicarbonate reabsorption.
- Effect of parathyroid hormone on erythropoiesis.