Effect of long-term aluminum feeding on lipid/phospholipid profiles of rat brain myelin
AUTOR(ES)
Pandya, Jignesh D
FONTE
BioMed Central
RESUMO
Effect of long-term (90–100 days) exposure of rats to soluble salt of aluminum (AlCl3) on myelin lipid profile was examined. The long-term exposure to AlCl3 resulted in a 60 % decrease in the total phospholipid (TPL) content while the cholesterol (CHL) content increased by 55 %. Consequently the TPL / CHL molar ratio decreased significantly by 62 %. The phospholipid composition of the myelin membrane changed drastically; the proportion of practically all the phospholipid classes decreased by 32 to 60 % except for phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Of the latter two, proportion of PC was unchanged while PE increased in proportion by 47 %. Quantitatively, all phospholipid classes decreased by from 42 to 76% with no change in the PE content. However the membrane fluidity was not altered in Al-treated rats. Many of the changes we observe here show striking similarities with the reported phospholipid profiles of Alzheimer brains.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=449727Documentos Relacionados
- Long-term effect of glucocorticosteroids on neuromuscular blocking in mice.
- Long-term potentiation and long-term depression: a clinical perspective
- Long-term hypotensive effect of atenolol 4% eyedrops.
- Long-term Effects of Terrorism on Children
- Long-term regulation of serotonergic activity in the rat brain via activation of protein kinase A.
