Effect of iNOS pharmacologic inhibitors in the insulin signalization and sensitivity in obese animal / Efeito de inibidores farmacologicos da iNOS na sensibilidade e sinalização de insulina em animais obesos

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

Nitric oxide synthase (NOS) has been divided into two major sub-enzymes, inducible NOS (iNOS) and constitutive NOS (cNOS). Although nitric oxide (NO) is an important defense mediator, the excessive production of NO has been involved in the pathology of many inflammatory and metabolic diseases. Some studies demonstrate that exogenous nitric oxide (NO) and the NO produced by iNOS can induce insulin resistance in muscle and plays an important role in fasting hyperglycemia. This study investigates the effect of a potent and selective iNOS activity inhibitor, the S-Methylisothiourea Iodide (SMT-I) 5 mg/kg per day, in fasting hyperglycemia and insulin resistance in diet-induced obesity model. We observed the metabolic parameters and Akt signalization and these findings provide evidence that the SMT-I treated group are protected against the development of insulin resistance, glucose intolerance and diet-induced obesity. Therefore, we propose that highly selective inhibitors of iNOS activity may represent a novel therapeutic approach for the therapy of insulin resistance and its complications as type 2 diabetes.

ASSUNTO(S)

diabetes mellitus oxido nitrico sintase resistência à insulina nitric oxide synthase diabetes mellitus tipo 2 type 2 insulin resistance

ACESSO AO ARTIGO

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