Effect of hypotonic expansion on sodium, water, and urea excretion in late pregnancy: the influence of posture on these results

AUTOR(ES)

Lindheimer, Marshall D.

RESUMO

Mineralocorticoid-treated, normotensive third trimester subjects positioned in lateral recumbency were studied before and during the infusion of 300 mEq of hypotonic saline. Urinary sodium excretion increased in all subjects from a mean value of 199 to 416 μEq/min. In 12 maximally hydrated subjects free water clearance (CH2O) and urine flow (V) increased from means of 7.54 and 9.50 to 11.6 and 14.5 ml/100 ml of glomerular filtrate (GFR) Also the ratio of urea to inulin clearance (Curea/Cinulin) increased from 0.59 to 0.64. The changes in the renal handling of water and urea suggest that fractional sodium reabsorption decreased at proximal nephron sites.

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