Effect of hydrophilic polymers on buccoadhesive eudragit patches of propranolol hydrochloride using factorial design
AUTOR(ES)
Patel, Vishnu M.
FONTE
Springer-Verlag
RESUMO
The purpose of this study was to develop formulations and systematically evaluate in vitro performances of buccoadhesive patches of propranolol hydrochloride using the hydrophobic polymer Eudragit L-100 as the base matrix. The hydrophilic polymers Carbopol 934 and polyvinyl pyrrolidone (PVP) K30 were incorporated into the Eudragit patches, to provide the patches with bioadhesive properties and to modify the rate of drug release. The patches, which were prepared by the solvent casting method, were smooth and elegant in appearance; were uniform in thickness, weight, and drug content; showed no visible cracks; and showed good folding endurance. A 32 full factorial design was employed to study the effect of independent variables like hydrophilic polymers Carbopol 934 and PVP K30, which significantly influenced characteristics like swelling index, ex vivo mucoadhesive strength, in vitro drug release, and ex vivo residence time. A stability study of optimized Eudragit patches was done in natural human saliva; it was found that both drug and buccal patches were stable in human saliva. It can be concluded that the present buccal formulation can be an ideal system to improve the bioavailability of the drug by avoiding hepatic first-pass metabolism.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2750360Documentos Relacionados
- Floating granules of ranitidine hydrochloride-gelucire 43/01: Formulation optimization using factorial design
- Effect of hydrophilic swellable polymers on dissolution enhancement of carbamazepine solid dispersions studied using response surface methodology
- Effect of organogel components on in vitro nasal delivery of propranolol hydrochloride
- Effect of resin content and pressing temperature on banana pseudo-stem particle boards properties using full factorial design
- Controlled release formulation of tramadol hydrochloride using hydrophilic and hydrophobic matrix system
