Effect of dietary magnesium deficiency on oxidative metabolism in tissues of rats submitted to exercise training / Efeito da deficiência dietética de magnésio no metabolismo oxidativo de tecidos de ratos submetidos a protocolo de treinamento periodizado

AUTOR(ES)

Aline Guimarães Amorim

DATA DE PUBLICAÇÃO

2007

RESUMO

This study aimed to verify if the ingestion of a diet poor in magnesium alters the oxidative metabolism in rats submitted to moderate physical activity. Male Wistar rats (initial body mass of 280 g) were divided into 4 groups: control (CON, n=9), exercised control (CONEX, n=9), deficient in Mg (MARG, n=9), and exercised and deficient in Mg (EXMARG, n=9). The control diet presented 500 mg of Mg/ Kg diet and the deficient diet contained 200 mg of Mg/ Kg diet. The animals were submitted to 6 weeks of swimming exercise, 1 hour/day, 5 time/week. Serum creatine kinase (CK) and lactate dehydrogenase (LDH) activity was obtained. Superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities were determined in skeletal muscles. Lipid peroxidation level (TBARS) was assayed in gastrocnemius and soleus muscles, liver and brain. Magnesium concentration was assayed in erythrocyte, serum, gastrocnemius and soleus muscles, liver, kydney and brain. Antioxidant enzyme activity was smaller on EXMARG group (p<0,05), especially in the citossol. possibly, these animals were more susceptible to oxidative damage, being difficult to execute the exercise, leading their effort near anaerobic level. However, the EXMARG group did not presented significant muscle TBARS concentration. The brain presented increased risk to magnesium deficiency pro-oxidative action. In summary, marginal magnesium deficiency in association with regular physical training led to a greater pro-oxidative action in the organism, specially over skeletal muscle.

ASSUNTO(S)

dano muscular physical exercise nutrição experimental dieta para esportistas (experimentos) muscle damage magnesium minerais na dieta (deficiência; experimentos) oxidative stress exercício físico deficiência dietética estresse oxidativo dietetic deficiency magnésio

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