Effect of decreased salivation and pH on the adherence of Klebsiella species to human buccal epithelial cells.
AUTOR(ES)
Ayars, G H
RESUMO
To assess the role of reduced salivary flow and intraoral pH on gram-negative bacterial colonization of the oropharynx, we studied in vitro Klebsiella adherence to normal human buccal epithelial cells at various pH values and to buccal cells from patients with pathological xerostomia (decreased saliva flow). Reduced pH significantly increased adherence of Klebsiella pneumoniae 84 to normal buccal epithelial cells (P less than 0.001). In contrast, two clinical isolates of K. oxytoca showed no significant pH-dependent change in adherence. A corollary of this was that patients with pathological xerostomia had significantly increased adherence of K. pneumoniae 84 to their buccal epithelial cells as compared with normal controls (P less than 0.01). These results suggest that reduced salivary flow and the concomitant reduction of intraoral pH may predispose patients to bacterial colonization with K. pneumoniae.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=347715Documentos Relacionados
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