Effect of cyclosporin A on murine natural killer cells.
AUTOR(ES)
Gui, X
RESUMO
In mice, cyclosporin A decreased the natural killer cell-enhancing effect of two interferon inducers, infective murine cytomegalovirus and nonreplicating Newcastle disease virus. It also inhibited murine cytomegalovirus replication at doses greater than 20 mg/kg, but it did not significantly inhibit interferon induction by Newcastle disease virus. In cell culture, cyclosporin A had no direct effect on the natural killer activity of spleen mononuclear cells derived from normal or murine cytomegalovirus-infected animals. However, at 50 micrograms/ml it significantly reduced the ability of interferon to enhance the natural killer activity of normal spleen cell suspensions. The inhibitory effect of cyclosporin A on natural killer cell activity in infected mice may be partly explained by its ability to block the action of interferon.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=551447Documentos Relacionados
- Effect of Toxoplasma infection on the sensitivity of mouse thymocytes to natural killer cells.
- Natural killer cell activity in chickens: target cell analysis and effect of antithymocyte serum on effector cells.
- Distinct organ-dependent mechanisms for the control of murine cytomegalovirus infection by natural killer cells.
- Human and murine inhibitory natural killer cell receptors transfer from natural killer cells to target cells
- Identification of an evolutionarily conserved, function-associated molecule on human natural killer cells.
