Effect of Cephalothin on Measurement of Creatinine Concentration
AUTOR(ES)
Rankin, Laura I.
RESUMO
Cephalothin, an antibiotic implicated as nephrotoxic, falsely elevates the creatinine concentration as determined by the Jaffé reaction in vitro. We studied this effect in vivo and demonstrated variable degrees of interference in determinations of plasma and urinary creatinine concentrations by two automated methods. Clinicians should be aware of this phenomenon in patients receiving cephalothin, both when monitoring renal function and when assessing patient reliability in the collection of timed urine specimens.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=352735Documentos Relacionados
- THE SERUM CREATININE CONCENTRATION OF NORMAL INDIVIDUALS 1
- Effect of Diuretics on Urinary Excretion of Cephalothin in Humans
- Effect of Clavulanic Acid on the Minimum Inhibitory Concentration of Benzylpenicillin, Ampicillin, Carbenicillin, or Cephalothin Against Clinical Isolates Resistant to Beta-Lactam Antibiotics
- Effect of Cephalothin on Renal Cortical Concentrations of Gentamicin in Rats
- A CLINICAL METHOD FOR THE APPROXIMATE DETERMINATION OF SERUM CREATININE CONCENTRATION