Effect of catecholamines on lymphopoiesis in fetal mouse thymic explants.

AUTOR(ES)

Singh, U

RESUMO

Fetal thymic explants (14 days of gestation) from Balb/c mice were grown in organ culture for up to 12 days and the pattern of lymphopoiesis was monitored by 125IUdR incorporation and cell yields of such lobes in the presence of adrenergic agents. It was observed that, after 3 days of cultures, phenylephrine stimulated lymphopoiesis in thymic explants, whereas some inhibition was observed with isoproterenol. These observations were confirmed by autoradiography. It was also observed that cells obtained from phenylephrine-treated cultures had greater mitogen reactivity than either control (untreated) or isoproterenol-treated cultures. The possible role of cyclic nucleotides as intracellular mediators of thymocyte maturation is discussed.

Documentos Relacionados

• Effect of Some Substituted Benzoic Acids and Related Compounds on the Distribution of Callus Growth in Tobacco Stem Explants. 12
• Activation of JAK2 tyrosine kinase by prolactin receptors in Nb2 cells and mouse mammary gland explants.
• Activity patterns and osmosensitivity of rat supraoptic neurones in perfused hypothalamic explants.
• Dopamine D2 receptor activation depolarizes rat supraoptic neurones in hypothalamic explants.
• Identification of a benzyladenine disaccharide conjugate produced during shoot organogenesis in Petunia leaf explants.