Effect of Calcium Carbonate on Bioavailability of Orally Administered Gemifloxacin
AUTOR(ES)
Pletz, M. W.
FONTE
American Society for Microbiology
RESUMO
We investigated the effect of calcium carbonate on the oral bioavailability of gemifloxacin. Gemifloxacin was administered alone, 2 h before, simultaneously, or 2 h after calcium carbonate in 16 volunteers. Data for 320 mg of gemifloxacin alone were as follows: maximum concentration of drug in serum (Cmax),13 μg/ml; half-life, 7.33 h; and area under the concentration-time curve from 0 h to infinity (AUC∞), 6.79 μg · h/ml. Only simultaneous coadministration of calcium carbonate reduced Cmax (−17%) and AUC∞ (−21%) significantly.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=161830Documentos Relacionados
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