Effect of atenolol pre-treatment in heart damage in a model of intestinal ischemia-reperfusion
AUTOR(ES)
Okada, Mieko, Falcão, Luiz Fernando Reis, Ferez, David, Martins, José Luiz, Errante, Paolo Ruggero, Rodrigues, Francisco Sandro Menezes, Caricati-Neto, Afonso, Marinho, Márcia, Fenelon, Guilherme, Oliveira-Júnior, Itamar Souza
FONTE
Acta Cir. Bras.
DATA DE PUBLICAÇÃO
2017-11
RESUMO
Abstract Purpose: To investigate the effects of atenolol in inflammatory mediator and oxidative stress in a myocardial injury by intestinal ischemia/reperfusion in rat model. Methods: Adult Wistar male rats were randomly (n=8), anesthetized and divided in: Sham: submitted to operation only; group SS+IR: intravenous saline infusion following superior mesenteric artery occlusion during 60 minutes (ischemia) and open for 120 minutes (reperfusion); group AT+IR: intravenous atenolol infusion (2 mg/kg) following superior mesenteric artery occlusion during 60 minutes (ischemia) and open for 120 minutes (reperfusion); and group AT+I+AT+R: intravenous atenolol infusion following superior mesenteric artery occlusion during 60 minutes (ischemia) and in the time 45 minutes other atenolol doses were administrated and the artery was open for 120 minutes (reperfusion), all animals were submitted to muscular relaxation for mechanical ventilation. In the end of experiment the animals were euthanized and the hearts tissue were morphology analyzed by histology and malondialdehyde by ELISA, and the plasma were analyzed for tumor necrosis factor-alpha by ELISA. Results: The group SS+IR demonstrated the higher malondialdehyde levels when compared with the atenolol treated-groups (p=0.001) in the heart tissue. The tumor necrosis factor-alpha level in plasma decrease in the treated groups when compared with SS+IR group (p=0.001). Histology analyses demonstrate pyknosis, edema, cellular vacuolization, presence of inflammatory infiltrate and band contraction in the heart tissue of the rats. Conclusion: Atenolol significantly reduce the degree of cardiac damage after intestinal ischemia-reperfusion.
Documentos Relacionados
- Cardioprotective Effect of Cilostazol on Ischemia-Reperfusion Injury Model
- Apoptosis and Histopathology of the Heart after Renal Ischemia-Reperfusion in Male Rat Running title: Ischemia-Reperfusion Injury
- Erratum: Apoptosis and Histopathology of the Heart after Renal Ischemia-Reperfusion in Male Rat Running title: Ischemia-Reperfusion Injury
- Tadalafil protector effect during ischemia-reperfusion in rats
- Neuroprotective effect of atorvastatin in spinal cord ischemia-reperfusion injury