Effect of altitude on oxygen binding by hemoglobin and on organic phosphate levels

AUTOR(ES)

Lenfant, Claude

RESUMO

The relationship between oxygen dissociation and 2,3-diphosphoglycerate (2,3-DPG) in the red cell has been studied in subjects moving from low to high altitude and vice versa. Within 24 hr following the change in altitude there was a change in hemoglobin affinity for oxygen; this modification therefore represents an important rapid adaptive mechanism to anoxia. A parallel change occurred in the organic phosphate content of the red cell. While this study does not provide direct evidence of a cause-effect relationship, the data strongly suggest that with anoxia, the observed rise in organic phosphate content of the red cell is responsible for increased availability of oxygen to tissues.

Documentos Relacionados

• The effect of cardiac disease on hemoglobin-oxygen binding
• Sequence of oxygen binding by hemoglobin
• Reciprocal binding of oxygen and diphosphoglycerate by human hemoglobin.
• Quaternary enhancement in binding of oxygen by human hemoglobin
• THE EFFECT OF ORAL ADMINISTRATION OF CALCIUM FRUCTOSE DIPHOSPHATE ON THE SERUM ORGANIC PHOSPHATE, INORGANIC PHOSPHATE, CALCIUM, PROTEIN, AND CITRIC ACID LEVELS 1