Efeitos neurofisiolÃgicos da dipirona sobre a depressÃo alastrante cortical em ratos jovens nutridos e desnutridos

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

The effectiveness of the action of certain drugs in the brain can vary as a function of its nutritional status during the development. Dipyrone is a drug that is very used in children, due to its analgesic and antipyretic effects. In rats, dipyrone also presents anticonvulsant effect. Considering the relationships between the epilepsy and the phenomenon known as cortical spreading depression (CSD), as well as the frequent use of dipyrone in children, in this work we investigated, in well-nourished- and early-malnourished rats, the impact, on CSD, of the treatment with dipyrone, for short periods (7 days) within the critical period of cerebral development. Wistar rats were suckled in lactation conditions considered favorable (litters with 6 pups, well-nourished group, n=76) or unfavorable (litters with 12 pups, malnourished group, n=69). Both nutritional groups received per gavage, during 7 days, either dipyrone (300mg/kg/d) or saline, during the 2nd, 3rd, or 4th week of life. At 35-45 days, CSD was recorded for 4h at 2 cortical points in the parietal region. In both W- and M-groups, dipyrone increased (P<0.05) the CSD-velocities, as compared to the respective saline-controls. This effect was more intense when dipyrone was applied at the fourth week of life, as compared to the other two weeks. For the W and M saline-treated groups, the meanÂsd velocities (in mm/min) were 3.70Â0.11, 3.77Â0.16 and 3.78Â0.13 (W-groups) and 4.13Â0.10, 4.16Â0.10 and 4.14Â0.09 (M-groups), for the animals treated in the 2nd, 3rd and 4th week of life. For the dipyrone-treated groups, the values were 3.99Â0.14, 4.03Â0.16 and 4.30Â0.19 (W-groups) and 4.47Â0.17, 4.70Â0.31 and 5.01Â0.28 (M-groups). Results support the hypothesis of a CSD facilitating effect of dipyrone, which is more intense at a late stage within the brain development period and is facilitated by early-malnutrition. This pioneer work represents a warning on the abusive use of certain therapeutical drugs in human developing organisms

ASSUNTO(S)

desenvolvimento cerebral depressÃo alastrante cortical brain development cortical spreading depression drug-nutrition interaction bioquimica interaÃÃo fÃrmacos-nutriÃÃo desnutriÃÃo precoce dipirona dipyrone early malnutrition

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