Efeitos dos Corticoesteróides no Crescimento Tardio das Lesões por Radiofrequência no Músculo da Coxa de Ratos Adultos, Púberes e Infantis. / Effects of corticosteroids on late extension of radiofrequency lesions in thigh muscle of adults, pubescent and infants rats.

AUTOR(ES)

Aparecida Mieko Okada Scafee

FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

25/08/2010

RESUMO

Background: Corticosteroids limit late enlargement of radiofrequency (RF) lesions in the thigh muscle of infant rats. However, their effects on pubescent and adult rats are unknown. Aim: To evaluate the effects of corticosteroids on the healing of RF lesions in the thigh muscle of rats at different ages. Methods: Ablation was undertaken in the thigh muscle of 30 rats (1 lesion per animal): infants (30 days old, weight 73g, n=10), pubescent (60 days old, weight 230g, n=10) and adults (90 days old, weight 310 g, n=10), divided into controls and treated animals, receiving Hydrocortisone (10mg/kg IM post-ablation) and Betametasone (3.5mg/kg IM twice a week for 29 days). Rats were sacrificed 60 days after ablation for histological and planimetric analysis using specific software. (ImageJ). Results: At follow-up, in infant, pubescent and adults, gain weight did not differ between controls and treated animals. In controls, lesions in infant and pubescent rats were larger (p=0.01) as compared to adults. Treatment reduced lesion size in infants (5.58+0.61mm vs. 4.02+0.23mm; p<0.01) and pubescent (5.20+0.47mm vs. 4.16+0.48mm; p<0.01) groups, but not in adults (4.44+0.50mm vs. 4.79+0.53mm, p=NS). Treated infant and pubescent rats showed less collagen deposition and less strands of fibrous tissue extending from the lesion into normal muscular tissue, characterizing clearly smaller lesions than their controls. No differences occurred in adult groups. Conclusion: Corticosteroids seem to reduce late lesion enlargement, in addition to attenuating fibrous proliferation in infant and pubescent rats.

ASSUNTO(S)

eletrofisiologia arritmias ablação por radiofrequência cardiologia

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