Efeitos do carbonato de lodenafila na consolidaÃÃo de fraturas da diÃfise femoral de Ratos tratados com haste intramedular / Effects of lodenafil carbonate on femoral diaphysis fractures healing in rats treated with intramedullary stem.

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

26/02/2010

RESUMO

The study was to investigate the effects of Lodenafil Carbonate in the process of bone healing in femurs of rats with reduced KirshnerÂs wire. The vascular factors are extremely important for the formation of callus. Lodenafil Carbonate cause vasodilatory effects, belongs to the group of selective phosphodiesterase type 5(PDE5) inhibitors, that enzyme inhibits cyclic guanosine monophosphate (GMPc) and relaxation of smooth muscles and are used to treat erectile dysfunction. It used 36 male rats, adult male rats, with the average weight of 300g. All animals underwent surgery in which fractures to the femoral shaft with a blunt guillotine. The animals were divided into 2 groups: lodenafil group, wich received oral doses of carbonate lodenafil (10mg/kg) and the control group. The animals were sacrificed at 7, 14 and 28 days postoperatively. There were two deaths, two false paths of the wire and three animals was not established fracture. Were performed radiographic studies with film mammography to analyze the optical density and area of callus, measured in mm  and histological study, using samples stained with picrosirius red under microscope light polarization, to quantify formation of collagen type I and type III in the cortical region near the fracture and callus. The density of type I collagen in the cortical region of the femur near the fracture observed in group lodenafil was significantly lower than that observed in the control group at 28 days of bone (** P = 0.0028). The results are not consistent enough to say that this drug has an effect on bone healing. It was found that the carbonate lodenafil not influence the process of bone healing in femurs of rats with reduced wire Kirshner.

ASSUNTO(S)

fisioterapia e terapia ocupacional inibidores de fosfodiesterase. fixaÃÃo intramedular de fraturas. consolidaÃÃo da fratura. phosphodiesterase inhibitors. fracture fixation, intramedullary. fracture healing.

ACESSO AO ARTIGO

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