Efeitos das isoflavonas da soja (Glycine max) na síntese de fatores vasoativos derivados de células endoteliais humanas da linhagem ECV304 / Effects of soy isoflavones (Glycine max) in the synthesis of vasoactive factors derived from human endothelial cells line ECV304.

AUTOR(ES)

Michele Paulo

DATA DE PUBLICAÇÃO

2008

RESUMO

During their reproductive years, women have a lower incidence of coronary heart disease (CHD) compared to men of similar age. However, this advantage disappears in post-menopause, suggesting that female sex hormones exert some cardio protective effect. One of the mechanisms proposed to explain this protection is the fact that estrogens promote the production of important vasoative factors by vascular endothelium, including nitric oxide and prostaglandin I2. By decreasing circulating estrogen, women in post-menopause are more susceptible of endothelial dysfunction and cardiovascular diseases. Studies have shown that the hormone replacement therapy (HRT) used by post-menopausal women in combating the symptoms of this period, improve endothelial dysfunction and lipid profile and increases the synthesis of vasoative factors, which help in the prevention of CHD. Meanwhile the HRT has been questioned by two large trials, the WHI (Writing Group for the Womens Health Initiative Investigators) and HERS (Heart and Estrogen/Progestin Replacement Study), which showed an increased risk of developing breast cancer and endometrial cancer in women using HRT. Among the alternative therapies to combat the symptoms of menopause and undesirable morbid implications that accompany this period, without exposing the patients to the side effects of HRT, the literature suggests the phytoestrogens, especially those from the soybean (Glycine max). The aim of this study is to evaluate the effect of isoflavones from soy, which are used by women in post-menopause, in the production of nitric oxide, prostaglandin E2 and endothelin-1 by endothelial cells, using an "in vitro" model: human endothelial cell line ECV304.

ASSUNTO(S)

isoflavonas da soja Óxido nítrico endothelial cell soy isoflavones células endoteliais prostaglandin and endothelin-1. prostaglandina e endotelina-1. nitric oxide

Documentos Relacionados

• Efeitos do polifenol resveratrol na síntese de fatores vasoativos do endotélio em células endoteliais humanas da linhagem ECV304
• Estudo comparativo da citotoxicidade de cimentos obturadores sobre culturas de células endoteliais da linhagem ECV 304
• Conidia aerobiology and cercosporiosis management of soybean (Glycine max)
• Prospection of antimicrobial peptides from soybean (Glycine max) using proteomics tools
• Docking de herbicidas na glutationa transferase tau4-4 de soja (Glycine max)