Efeitos da separação materna sobre o comportamento, a imunidade inata e o crescimento tumoral / Maternal separation effects on the behavior, innate immunity and tumor growth

AUTOR(ES)
DATA DE PUBLICAÇÃO

2008

RESUMO

Maternal separation is one model of stress/anxiety induction. We know about it that the mammals normal emotional behavior development depends on the interaction between mother and younglet. Beside this, early life stressed events can induce deletery effects in immune response and to illness resistance for all life long. In this work we searched for the maternal separation effects on the behavior, innate immunity and tumor growth in an adult male mice offspring. Our results showed that the maternal separation, in A/J mice (1) had no big effects in the behavior and in the hematological parameters (before and after the tumor growth), (2) increased the neutrophil and alveolar macrophages activity (before and after the tumor growth), (3) increased the serotonin striatum levels, the 5-HIAA metabolite and the dopamine turnover (4) decreased the corticosterone serum levels and (5) had no effects on tumor incidence. In the C57BL/6 mice, the maternal separation induced an anxiety behavior and increased the neutrophil activity. These results suggest that the maternal separation could have produced alterations in neuroimmune activity, modifying the HPA axis activity and these alterations could be influenced by individual strains characteristics.

ASSUNTO(S)

mazes neuroimmunomodulation citometria de fluxo flow citometry stress natural immunity labirintos stress ansiedade de separação neuroimunomodulação separation anxiety imunidade natural

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