Efeitos da risperidona e do haloperidol em um modelo de esquizofrenia induzido pela cetamina em camundongos / Effects of risperidone and haloperidol in a model ketamine-induced schizophrenia in mice

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

01/08/2008

RESUMO

This study presents the actions of the antipsychotics (APC) risperidone (Risp) and haloperidol (Hal) on the behavioral effects elicited by Cetamine (Ceta), in mice in the following tests: Open-field (OF), Rota rod (RR) Tail suspension (TS), Elevated Plus-maze (EPM)- (Time in open arms-TOA; Time in closed arms -TCA), Hole Board (Time of head-dip -THD, number head-dips-NHD) and Active social interaction (Time social interaction -TSI). Thus, animals used were male Swiss albino mice (25-30 g). Drugs were administered alone (Risp: 0.1 or 0.2 mg/kg, ip; Hal: 0.1 and 0.2 mg/kg, ip) or thirty minutes before Ceta (10 mg/Kg, ip). The results showed that Ceta increase (Ceta: 63.3 4.2) and APC decreased the locomotor activity as compared to control (25.5 4.2). Mice pretreated with APC, at both doses, blocked hyperlocomotion caused for Ceta. In RR, Ceta decreased (Ceta: 15 4.1) the permanence time of the animals as compared to control (Control: 59 0.6) and this effect did not observed with APC alone. Pretreatment with APC reverted the effect of Ceta alone in the RR. While Ceta (17.3 5.6) decreased the time of immobility, in the TS test, as compared to control (80.2 10.2), the pretreatment with APC reverted this mobility. In EPM Ceta incresed (112.814) the TOA compared to Control (30.512), APC decresed TOA (Hal 0.1: 16.94.5; Risp 0.1: 2313.8; Risp 0.2: 0.90.6), pretreatment at higher dose (Hal 0.2+Ceta: 33.621; Risp 0.2+Ceta : 00), reverted effect of the Ceta alone. The TCA of the Ceta alone (122.510.4) was shorter than Control Group (223.714.5), and this effect was reverted with pretreatment at higher dose (Hal 0.2+Ket: 23324.3; Risp 0.2+Ceta: 276.515.2). APC as well as Ceta (101.2) decresed the THD compared at Control (13.31.1). APC and Ceta (16.82.8) decresed the TSI compared at Control (46.66.5) and pretreatment with APC not reverted the effect of the Ceta alone. The action of neuroleptics in this model has made blockade of effects caused by acute administration of Cetamine. Thus, we suggest that the mechanism of action of Cetamine involve the dopaminergic system.

ASSUNTO(S)

esquizofrenia cetamina antipsicóticos camundongos fisiologia schizophrenia cetamine antipsychotics mice

ACESSO AO ARTIGO

Documentos Relacionados