"Efeitos da infusão de Luffa operculata sobre o epitélio e a atividade mucociliar do palato isolado de rã" / Effects of Luffa operculata infusion on the epithelium and the mucociliary activity of the isolated frog palate

AUTOR(ES)
DATA DE PUBLICAÇÃO

2004

RESUMO

Luffa operculata is a medicinal plant popularly used for treatment of rhinitis and rhinosinusitis. Its dry fruit infusion is used into the nose, delivering profuse mucous secretion, but may cause nasal mucosa irritation, epistaxis or anosmia. We evaluated the effects of different concentrations of Luffa operculata dry fruit infusion on mucociliary transport velocity (MTV), ciliary beat frequency (CBF), transepithelial potential difference (TPD) and epithelial morphology (light and electron transmission microscopy) of the isolated frog palate preparation. Results pointed to dose-dependent epithelial damage on mucociliary epithelium, suggesting that it is potentially noxious to the human nasal mucosa

ASSUNTO(S)

luffa operculata sinusite/terapia mucosa nasal/efeitos de drogas rhinitis/therapy junÇÕes Íntimas/efeitos de drogas medicina herbÁria mucociliary clearance plantas medicinais/toxicidade rana catesbeiana tight junctions/drug effects rinite/terapia plants medicinal rana catesbeiana luffa operculata depuraÇÃo mucociliar plantas medicinais/uso terapêutico nasal mucosa/drug effects medecine herbal plants medicinal/toxicity sinusitis/therapy

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