Efeitos da ghrelina, GHRP-6 e GHRH sobre a secreção de GH, ACTH e cortisol em pacientes com diabetes mellitus tipo 1 / Effects of ghrelin, GH-releasing peptide-6 (GHRP-6) and GHRH on GH, ACTH and cortisol release in type 1 diabetes mellitus

AUTOR(ES)

Larissa Bianca Paiva Cunha de Sa

DATA DE PUBLICAÇÃO

2009

RESUMO

In type 1 diabetes mellitus (T1DM), GH responses to provocative stimuli are normal or exaggerated while the hypothalamic-pituitary-adrenal axis has been less studied. Ghrelin is a GH-secretagogue which also increases ACTH and cortisol levels, similarly to GHRP-6. GhrelinLs effects in patients with T1DM have not been evaluated. We, therefore, studied GH, ACTH and cortisol responses to ghrelin and GHRP-6 in 9 patients with T1D1 (HbA1c: 11.7}1.3%; mean}SE) and 9 control subjects. GHRH- induced GH release was also evaluated. Mean basal GH levels (Rg/L) were higher in T1DM (3.5}1.2) than in controls (0.6}0.3). Analyzing AUC GH values (Rg/L.120min), no significant differences were observed in T1DM (ghrelin: 3148}427; GHRP-6: 1428 }299; GHRH: 885 }184) compared to controls (ghrelin: 3228}1036; GHRP-6: 1271}217; GHRH: 643}178). In both groups, ghrelin-induced GH release was higher than after GHRP-6 and GHRH. There was a trend (p=0.055) to higher mean basal cortisol values (Rg/dL) in T1DM (11.7}1.5) compared to controls (8.2}0.8). No significant differences were seen in AUC cortisol values (Rg/dL.90min) in both groups after ghrelin (DM1:303}106; controls: 467}86) and GHRP-6 (DM1:135}112; controls: 187}73). Mean basal ACTH values (pg/mL) were similar in T1DM (19.9}3.4) and controls (14.5}2.3). No differences were seen in AUC ACTH levels (pg/mL.90min) in both groups after ghrelin (DM1:1372}771; controls: 1394}327) and GHRP-6 (DM1: 257}291; controls: 423 }211). In summary, patients with T1DM have normal GH responsiveness to ghrelin, GHRP-6 and GHRH. ACTH and cortisol release after ghrelin and GHRP-6 is also similar to controls. Our results suggest that chronic hyperglycemia of T1DM does not interfere with GH, ACTH and cortisol releasing mechanisms stimulated by these peptides.

ASSUNTO(S)

ghrelina gh acth cortisol diabetes mellitus tipo 1 endocrinologia ghrelin gh acth cortisol type 1 diabetes mellitus

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