Efeito do polissacarideo da soja sobre o aparelho digestivo : avaliação da produção de hidrogenio e da permeabilidade intestinal a lactulose

AUTOR(ES)
DATA DE PUBLICAÇÃO

1992

RESUMO

The study was carried out in 13 healthy male or female volunteers, aged 23-38 years old, with no known active gastrointestinal disease. Subjects consumed a meal consisting only of rice and meat on the night prior to the study. On each study day , the subjects received 1 of 3 test meals on 3 different days - The 3 test meal consisted of the following: 20 g of lactulose, 20 g of lactulose plus 30 g of soy polysaccharide, 30 g of soy polysaccharide. Samples of expired air were collected in syringes. Breath hydrogen concentration was determined by gas chromatography and collected every 15 minutes for 8 hours with the first sample just prior to the ingestion of the test meal. Water up to 800 ml was allowed throughout the study. Ho food was allowed during the first 6 hours of the study, after wich a plain hamburguer was eaten by the subjects. Curves of breath hydrogen concentration were analysed according to the area under the curve and the time ta a sustained rise.On the day that the subjects ingested lactulose alone or with soy polysaccharide, urine for lactulose determination was collected and analysed by the "thin-layer chromatography". The symptoms were scored on each study day. The results showed that soy polysaccharide was unable to produce symptoms or increase the H2 production. No significant relationship was found between the ingestion of soy polisaccharide plus lactulose and the production of sugar intolerance symptoms, even though all but 5 had had less symptoms. When soy polisaccharide was ingested with lactulose by the subjects, the urinary lactulose recovery decreased

ASSUNTO(S)

aparelho digestivo gastroenterologia

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