Efeito do óleo essencial de Pterodon polygalaeflorus benth em músculo liso intestinal de rato. / Effect of essential oil in Pterodon polygalaeflorus benth intestinal smooth muscle of rat.

AUTOR(ES)

Valéria Leonhardt

FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

09/04/2008

RESUMO

This study investigates the effects of essential oil of Pterodon polygalaeflorus (EOPP) and b-caryophyllene (b-CAR). EOPP and b-CAR relaxed the basal tone of ileum smooth muscle in a concentration-dependent manner (IC50s = 394.35 62.12 and 68.65 9.51 lg/mL respectively), an effect that was unaltered by hexamethonium, L-nitroarginine methyl ester or indomethacin. Both EOPP and b-CAR evoked a concentration-dependent relaxation of ileum pre-contracted with KCl with an IC50 value of 107.78 10.47 and 17.35 0.75 lg/mL, respectively. EOPP and b-CAR inhibited the contractions induced by acetylcholine (ACh) and by KCl. In ileal preparations, the CaCl2-induced contractions were reduced by EOPP (300 lg/mL) and b-CAR (100 lg/mL). Furthermore, CaCl2-induced contractions were also reduced by EOPP (300 lg/mL) and b-CAR (100 lg/mL) in ileal preparations pretreated with ACh under Ca2+-free condition and in the presence of verapamil. EOPP (100 and 300 lg/mL) and b-CAR (30 and 100 lg/mL) reduced the ACh-induced contractions of isolated rat ileum under Ca2+-free conditions. In the presence of high KCl and Ca2+-free conditions, EOPP (300 lg/mL) and b-CAR (100 lg/mL) reduced the contractions induced by barium. A similar effect was also observed with verapamil. It is concluded that (i) b-CAR is an important constituent involved in the myorelaxant and antispasmodic effects induced by EOPP; (ii) the inhibitory effect on intestinal contractility is myogenic and seems mainly mediated through an intracellular mechanism. However, the ability of EOPP and b- CAR to decrease Ca2+ influx through cytoplasmic membrane could not be discounted.

ASSUNTO(S)

pterodon polygalaeflorus benth fisiologia de orgaos e sistemas pterodon polygalaeflorus benth

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