Efeito do estrogeno e da calcitonina sobre o reparo e densidade ossea ao redor de implantes de titanio inseridos em ratas ovariectomizadas

AUTOR(ES)
DATA DE PUBLICAÇÃO

2003

RESUMO

This study evaluated whether estrogen (E) and calcitonin (CT) administration could influence bone healing and bone density around implants placed in ovariectomized rats (OVX). Twenty-one days betore implant placement, bilateral ovariectomies were performed trom a dorsal approach. One screw-shaped titanium implant was placed bilaterally. The animais were assigned to one of the tollowing groups: Group 1 (n=15): sham surgeries; Group 2 (n=15): OVX rats; Group 3 (n=14): OVX rats subcutaneously administered with calcitonin (CT) 4 days/week (16 IU/Kg); Group 4 (n=14): OVX rats subcutaneously administered with 1713 estradiol daily (20Jlg/Kg). After sixty days, the animais were sacrificed and undecalcified sections obtained. Bone density (8D) (the proportion of mineralized bone in a 500 Jlm-wide zone lateral to the implant), bone-to-implant contact (B/C) and bone area (BA) around the implants were obtained and arranged separately for the cortical (Zone A) and cancellous(Zone B). In Zone A, intergroup analysis revealed no significant difference regarding BIC and BD (P>0.05). In contrast, the group 4 presented a greater bone area than groups 2 and 3 (P<0.05). Data trem Zone B revealed that estrogen nullified the negative effect of the ovariectomy on BD, BIC and BA (P<0.05), while CT presented no effect (P>O.05). Therefore, E-therapy may prevent the influence that endogenous estrogen deficiency exerts on bone healing and bane density around titanium implants

ASSUNTO(S)

periodontia hormonios implantes dentarios endoosseos

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