Efeito do esteroide anabolico nandrolona sobre o nivel de ansidade em ratos / Anabolic steroids effects on anxiety level of rats

AUTOR(ES)
DATA DE PUBLICAÇÃO

2006

RESUMO

Androgenic anabolic steroids (AAS) are used for the treatment of male hypogonadism, andropause associated with elderly, osteoporosis, anemia associated with kidney failure, acquired immunodeficiency disease syndrome, politraumatism and postsurgery periods. However, the AAS abuse and non-therapeutic use, in higher doses show side effects, including mood alteractions, aggressiveness and higher suicide incidence. The aim of this study was to evaluate the nandrolone decanoate effect on the anxiety levels in rats. Male Wistar rats (2 mo.) were randomly divided into 6 groups (n = 12-15/groups: control, vehicle, nandrolone, control + diazepam, vehicle + diazepam, and nandrolone + diazepam. The vehicle or nandrolone treated animals received injection of propilenglycol (0,2mL/Kg, i.m.) or nandrolone decanoate (0,5 mg/Kg i.m.), respectively, twice a week, for 6 weeks. Control group rats were subject only to procedures related to their routine living conditions. By the end of 6 weeks, all groups were submitted to the elevated pluz maze (EPM), 24 hours after the last vehicle or nandrolone injection, or equivalent period for the control group. In order to pharmacological validation, some animals were treated with diazepam (1 mg/Kg i.p.) 30 min before the EPM. Data were analyzed by Two-way ANOVA and post-hoc Tukey test (p<0,05). Nandrolone treated animals showed less percentage of time spent in the open arms (1.46 ± 0.49) compared with control (3.80 ± 0.97) and vehicle (3.96 ± 0.85 %) groups. Nandrolone treated animals also showed less percentage of open arms entries (6,00 ± 1,67) in relation to vehicles groups (15,06 ± 2,80) and control groups (16,75 ± 3,30 %). However, nandrolone did not promote any changes in enclosed arms entries, risk assessment and final open arms end- exploring. Diazepam treatment reverted the effects of nandrolone in the time and entries percentage in the open arms. The present data showed that the treatment with a high dose of nandrolone decanoate induced an increase in the anxiety level in rats

ASSUNTO(S)

diazepam anxiety diazepam ansiedade

ACESSO AO ARTIGO

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