Efeito da temperatura febril sobre o fenótipo e função de células dendríticas derivadas de monócitos sangüineos. / Effect of fever-range temperature on monocyte-derived dendritic cell phenotype and function.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2008

RESUMO

Dendritic cells (DCs) are the main antigen presenting cells and susceptible to many activation signals that will induce different patterns of DC activation and of T cell responses. In this work we studied the effects of two danger signals, fever and LPS, on DC phenotype and function. Exposure of immature monocyte-derived dendritic cells to heat did not affect CD80 and CD86 expression, their endocytic ability, or their cytokine production, characteristics that were affected by LPS. However, heat-exposed DCs presented a higher allo-stimulatory activity and enhanced CD40 expression. When LPS activated DCs were also stimulated by heat, no cell surface phenotypic change was noted but these cells induced a higher IFN-g secretion by allogeneic T lymphocytes and favored the proliferation of CD8+ cells. These data indicate that fever may cause a bias toward cellular responses, through its action on activated DCs, probably through CD40. Besides its physiological meaning, this phenomenon may have applications in immunotherapeutic strategies.

ASSUNTO(S)

molecules coestimuladoras dendritic cells fever bacterial endotoxin moléculas coestimuladoras febre hipertermia hyperthermia endotoxina bacteriana células dendríticas

ACESSO AO ARTIGO

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