Efeito da mistura polpa de laranja/goma-guar sobre parametros bioquimicos e cardiovasculares em hamsters alimentados com dieta hipercolesterolemica

AUTOR(ES)
DATA DE PUBLICAÇÃO

2004

RESUMO

Several studies have been demonstrating that the dietary fibers exercise protecting effects against the harmful impact of the hyperlipidemie. The orange pulp/guar-gum mix (110:40) was used as source of dietary fiber and characterized presenting the following physical-chemically composition: total fiber, 76,12%; soluble fiber, 43,54; insoluble fiber, 32,58. The hypolipidemics effects of the orange pulp/guar-gum mix (PLG) were verified in young male adults hamsters submitted to hypercholesterolemic diets being appraised biochemical, cardiovascular, morphometric, and ultrastructurals parameters. The PLG mix added to hypercholesterolemic diets was effective in reducing the plasma triacylglicerol levels (78,8%), total cholesterol (29,2%) what was reflected in the hepatic lipid incorporation that was reduced in 28,6%. The fecal analysis showed that the animals that consumed the hypercholesterolemic diet enriched of the PLG mix (group HF) presented increase of 37,89% in the fecal cholesterol excretion. The heart steatosis were reduced in the hypercholesterolemic animals fed PLG mix, reduction of 58% was verified in the lipids droplet in the citosol of the cardiac cells. PLG added in the hypercholerolemic diet reduced blood pressure significantly (23,2%) and heart rate (12,9%), in relation to the hypercholesterolemic group without PLG added. These results reflected in the deviation of the ventricular eletric axis that in hypercholesterolemic animals moved for the left (SÂQRS = 11º) suggesting ventricular hypertrophy, with long QTc interval (408,1 ms). In ultraestrutural response, the animals of the HF group presented larger responsivity of the catecholamines adrenergic response reducing the displacement dose-response curve for the right. In conclusion, the hipocholesterolemic effects of the PLG mix can be attribuid of the physico-chemical capacity biliary acid of adsorption and the lipids of the diet that brings those materials to the feces, but also the short chain fatty acid formation in the large intestine that, reduces the activity of the 3-OH-metil glutaril CoA reductase, key enzyme in the cholesterol biosynthesis. In our laboratory we identify that the orange pulp presents antioxidant potential in hamsters fed with hypercholesterolemic diet. This possible that antioxidant effect can collaborate for the reduction of LDL components oxidation, a decisive event in the atherosclerosis genesis and preserving the nitric oxide (NO) against oxidation by oxigen reactive species (free radicals) that convert it in peroxinitrite acid (ONOOH) that can decomposed in a great amount of toxic products as NO2 ?, OH?, and also NO2 +

ASSUNTO(S)

colesterol coração hamster como animal de laboratorio lipidios

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