Efeito da crotapotina na evolução clinica da neurite experimental autoimune (EAN) / Effect of crotapotin on clinical evolution of experimental autoimmune neuritis

AUTOR(ES)
DATA DE PUBLICAÇÃO

2006

RESUMO

Biomedical research in which venom components are being investigated for their potential as novel therapeutic agents has emerged as an interesting option. Crotapotin which is a fraction of the venom of the rattlesnake Crotalus durissus terrificus, has been described as an antinflammatory that acts on the innate arm of the immune response. Here we have demonstrated that intraperitoneal (IP), as well as oral administration of crotapotin significantly reduces the severity of experimental autoimmune neuritis (EAN), an experimental model for Guillain-Barré Syndrome. The reduction of the severity of the disease is associated with a reduction in the mononuclear cells infiltrating in the sciatic nerve and a significant decrease in the lymphocyte proliferative response to neuritogenic peptide

ASSUNTO(S)

sindrome de guillain-barre crotalus neurite neuritis guillain-barre syndrome crotoxin doenças auto-imunes peripheral nervous system diseases crotoxina autoimmune diseases doenças do sistema nervoso periferico

ACESSO AO ARTIGO

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