Efeito da administração intermitente de PTH na periodontite induzida em ratas com deficiencia de estrogeno

AUTOR(ES)
DATA DE PUBLICAÇÃO

2004

RESUMO

Parathyroid hormone (PTH) intermittent administration, a bone anabolic treatment, has been used to treat bone mass decrease in estrogen deficient or/and osteoporotic individuals. Objectives: The aim of this study was analyze the effects of PTH intermittent administration on the periodontitis progression, in ovariectomized rats. Methods: Thirty female rats were set in 3 groups. The rats of the B and C groups were ovariectomized, and the A group was sham operated. The animals received cotton ligature around the first left lower molar, the right molars were left unligated working as control. The C group received PTH doses (40µg/Kg), and the A and B groups received the same dose of the vehicle, three times week. After 30 days the animals were sacrificed, the mandibles were extracted, Xrayed and samples were prepared to obtain decalcified histological sections, scanning electron microscopy of the tibia was also performed to evaluate possible changes in bone structure caused by estrogen deficiency. Results: The samples analyzed under light microscopy, using an image analyzer software for bone loss measurement (mm2) showed: Group A: 0.40b; Group B: 0.48b; Group C: 0.21a; where different letters indicate statistical significant differences among groups p<0.05 (ANOVA and Tukey’s tests). The photodensitometer analysis demonstrated a lower mandibular bone density in the ovariectomized group that did not receive PTH treatment (p<0.01), results corroborated by SEM images. Conclusions: Despite of the presence of a periodontitis inductor and estrogen deficiency, PTH intermittent doses were able to reduce alveolar bone loss, in ovariectomized rats.

ASSUNTO(S)

hormonios doença periodontal

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