Early discordant binocular vision disrupts signal transfer in the lateral geniculate nucleus.
AUTOR(ES)
Chino, Y M
RESUMO
The mammalian lateral geniculate nucleus (LGN) is known to regulate signal transfer from the retina to the brain neocortex in a highly complex manner. Besides inputs from the brainstem, extraretinal inputs via corticogeniculate projections and local inhibitory neurons modulate signal transfer in the LGN. However, very little is known about whether the postnatal development of LGN signal-transfer mechanisms is influenced by early discordant binocular vision. By intraunit comparisons of responses between individual X-LGN cells and their direct retinal inputs, the efficiency of signal transfer was found permanently reduced due to an early interocular misalignment (strabismus). The contrast sensitivity and spatial resolution of cat LGN cells were significantly lower relative to their retinal inputs, and there was substantial decrease in signal-transfer speed. The observed physiological deficits were associated with immature X-retinogeniculate axon arbors. Thus, contrary to previous ideas, conflicting binocular inputs can produce neural deficits in subcortical visual structures.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=44313Documentos Relacionados
- Spatio-temporal interaction in neurones of the cat's dorsal lateral geniculate nucleus.
- Organization and post-natal development of the monkey's lateral geniculate nucleus.
- The length-response properties of cells in the feline dorsal lateral geniculate nucleus.
- The binocular input to cells in the feline dorsal lateral geniculate nucleus (dLGN).
- Brainstem control of response modes in neurons of the cat's lateral geniculate nucleus.