Dynamics of fever and serum levels of tumor necrosis factor are closely associated during clinical paroxysms in Plasmodium vivax malaria.
AUTOR(ES)
Karunaweera, N D
RESUMO
Paroxysms are sharp episodes of high fever accompanied by chills and rigors that occur periodically, once in every 48 hr in Plasmodium vivax infections. We have measured the changing levels of serum tumor necrosis factor (TNF) during paroxysms in non-immune patients infected with P. vivax malaria. The changes in TNF levels closely paralleled the rise and fall in temperature during the paroxysms but tended to precede them by 30-60 min. These observations suggest that the rise and fall in temperature during P. vivax paroxysm may be directly related to the periodic changes in TNF levels induced during these infections. The peak TNF levels reached during P. vivax infections were much higher than even those which have been recorded during severe and fatal P. falciparum infections in which TNF has been postulated to contribute to the severe manifestations of this disease.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=48833Documentos Relacionados
- Tumor necrosis factor alpha and the anemia associated with murine malaria.
- Evolution of the levels of soluble interleukin-2 receptors during Plasmodium falciparum and P. vivax malaria.
- Levels of stem cell factor and interleukin-3 in serum in acute Plasmodium falciparum malaria.
- Antimalarial effects of rifampin in Plasmodium vivax malaria.
- Serological relationship of tumor necrosis factor-inducing exoantigens of Plasmodium falciparum and Plasmodium vivax.