Duodenal jejunal bypass attenuates non-alcoholic fatty liver disease in western diet-obese rats

AUTOR(ES)

Ebertz, Claudia Emanuelli, Bonfleur, Maria Lúcia, Bertasso, Iala Milene, Mendes, Mariana Carla, Lubaczeuski, Camila, Araujo, Allan Cezar de Freitas, Paes, Antônio Marcus, Amorim, Elaine Manoela Porto de, Balbo, Sandra Lucinei

FONTE

Acta Cir. Bras.

DATA DE PUBLICAÇÃO

2014-09

RESUMO

PURPOSE:To evaluate the effects of duodenal-jejunal bypass (DJB) on serum and hepatic profiles of obese rats fed on a western diet (WD).METHODS: Twenty eight male Wistar rats were fed a standard rodent chow diet (CTL group) or WD ad libitum. After 10 weeks, WD rats were submitted to sham (WD SHAM) or duodenal-jejunal bypass (WD DJB). Body weight, fat pad depots, glycemia, insulinemia, HOMA-IR, TyG, lipids profile and hepatic analyses were evaluated two months after surgery.RESULTS:The WD SHAM group presented greater obesity, hyperglycemia, hyperinsulinemia, insulin resistance, hypertriglyceridemia and hepatic steatosis than the CTL group. WD DJB rats presented decreased serum glucose and insulin resistance, when compared to WD SHAM animals, without changes in insulinemia. In addition, DJB surgery normalized serum TG and attenuated TG accumulation and steatosis in the liver of the WD DJB group. Hepatic ACC and FAS protein expressions were similar in all groups.CONCLUSION:Duodenal-jejunal bypass attenuates hepatic parameters of non-alcoholic fatty liver disease in obese rats fed on a western diet.

Documentos Relacionados

• SARCOPENIA AND SEVERITY OF NON-ALCOHOLIC FATTY LIVER DISEASE
• IMPACT OF CURRENT DIET AT THE RISK OF NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD)
• Transient elastography in patients with non‐alcoholic fatty liver disease (NAFLD)
• Non‐alcoholic fatty liver disease in patients with HCV genotype 4
• Effects of duodenal-jejunal bypass on structure of diaphragm in western diet obese rats