Drosophila telomere transposon HeT-A produces a transcript with tightly bound protein.

AUTOR(ES)

Danilevskaya, O N

RESUMO

Telomeres from Drosophila appear to be very different from those of other organisms. A transposable element, HeT-A, plays a major role in forming telomeres and may be the sole structural element, since telomerase-generated repeats are not found. The structure of the HeT-A element, deduced from cloned fragments of DNA, suggests that transposition of the element is mediated by a polyadenylylated RNA intermediate. We now report analyses of HeT-A transcripts. The major RNA is of the appropriate size and strandedness to serve as a transposition intermediate. This RNA is found in cultured cells and in intact flies and is unusual in that it is associated with protein after treatments that apparently remove all protein from other RNAs.

Documentos Relacionados

• Unusual features of the Drosophila melanogaster telomere transposable element HeT-A are conserved in Drosophila yakuba telomere elements
• HeT-A elements in Drosophila virilis: Retrotransposon telomeres are conserved across the Drosophila genus
• Frequent transpositions of Drosophila melanogaster HeT-A transposable elements to receding chromosome ends.
• Attachment of HeT-A Sequences to Chromosomal Termini in Drosophila melanogaster May Occur by Different Mechanisms
• HeT-A, a transposable element specifically involved in "healing" broken chromosome ends in Drosophila melanogaster.