Double-stranded RNA antibodies in systemic lupus erythematosus.
AUTOR(ES)
Davis, P
RESUMO
Antibodies to viral double-stranded RNA (ds RNA) have been found in 40% of patients with systemic lupus erythematosus (SLE) and 14-5% of patients with rheumatoid arthritis. These antibodies were diagnostically more specific SLE than those directed against artificial polynucleotides, poly I:C and poly A:U. Although not disease specific, high titres of antibody to ds viral RNA were found almost exclusively in SLE. Serial studies failed to show that RNA antibody levels correlated with disease activity. Although of considerable interest in experimental studies on the pathogenesis of SLE, ds viral RNA antibodies are of little clinical significance in the management of SLE.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1006404Documentos Relacionados
- Antibodies to protein P in systemic lupus erythematosus.
- A deletion mutant of L-A double-stranded RNA replicates like M1 double-stranded RNA.
- Selective removal of anti-double-stranded DNA antibodies by immunoadsorption with dextran sulphate in a patient with systemic lupus erythematosus.
- Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNA-activated p68 kinase.
- In vivo expression of a single viral DNA-binding protein generates systemic lupus erythematosus-related autoimmunity to double-stranded DNA and histones.