Double-dose hepatitis B vaccination in cirrhotic patients on a liver transplant waiting list
AUTOR(ES)
Bonazzi, Patricia R., Bacchella, Telesforo, Freitas, Angela C., Osaki, Karina T., Lopes, Marta H., Freire, Maristela P., Machado, Marcel C.C., Abdala, Edson
FONTE
Brazilian Journal of Infectious Diseases
DATA DE PUBLICAÇÃO
2008-08
RESUMO
Development of immunity to hepatitis B virus in cirrhotic patients waiting for liver transplantation is highly desirable. Though a double-dose regimen is available, little is know about its effectiveness. We examined the efficacy of double-dose hepatitis B virus vaccination in cirrhotic patients waiting for liver transplantation. We studied 43 patients who were waiting for liver transplantation. They were vaccinated with three doses of 40 mg hepatitis B vaccine at 0, 1 and 6 months; the normal dose is 20 mg. Efficacy was measured based on seroconversion of anti-HBs. Global response to the primary vaccination scheme was 67.5% (29 patients). Forty-one per cent of responders had anti-HBs titers above 1,000 IU/mL. No factors were associated with response, based on multivariate analysis. The vaccination scheme of 40 mg at 0, 1 and 6 months was superior to conventional vaccination doses (20 mg) for cirrhotic patients on a waiting list for liver transplantation.
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