Dosage Compensation in DROSOPHILA MELANOGASTER Triploids. II. Glucose-6-Phosphate Dehydrogenase Activity
AUTOR(ES)
Maroni, Gustavo
RESUMO
The level of activity of the enzyme glucose-6-phosphate dehydrogenase was determinel in flies having seven different chromosomic constitutions. All those having an integral number of chromosomes [XAA, XXAA, XAAA, XXAAA, and XXXAAA (X=X chromosome, A=set of autosomes)] were found to have similar units of enzyme activity/mg live weight, while diploid females with a duplication and triploid females with a deficiency showed dosage effect. The amount of enzyme activity per cell, on the other hand, is also independent of the number of X's present but appears roughly proportional to the number of sets of autosomes.—It is proposed that dosage-compensated sex-linked genes are controlled by a positively acting regulatory factor(s) of autosomal origin. With this hypothesis it is possible to explain dosage compensation as a consequence of general regulatory mechanisms without invoking a special device which applies only to the X chromosomes.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1212948Documentos Relacionados
- Effect of Sex Transformation Genes on Glucose-6-Phosphate Dehydrogenase Activity in DROSOPHILA MELANOGASTER
- Complete concordance between glucose-6-phosphate dehydrogenase activity and hypomethylation of 3' CpG clusters: implications for X chromosome dosage compensation.
- Glucose-6-phosphate dehydrogenase activity in erythrocytes of experimental animals
- Inherited Variation in the Dehydrogenases of Doves (Streptopelia). II. Autosomal Inheritance of Glucose-6-Phosphate Dehydrogenase
- Glucose-6-phosphate dehydrogenase (G6PD) activity of human sperm.